Correction: Objective Acoustic Quantification of Phonatory Dysfunction in Huntington's Disease

Objective Acoustic Quantification of Phonatory Dysfunction in Huntington's Disease

PURPOSE Although speech motor changes are reported as a common sign of Huntington's disease (HD), the most prominent signs of voice dysfunction remain unknown. The aim of the current study was to explore specific changes in phonatory function in subjects with HD. METHOD 34 subjects with HD and 34 age- and sex-matched healthy controls were examined. Participants performed sustained vowel phona...

Phonatory Dysfunction as a Preclinical Symptom of Huntington Disease

PURPOSE Although dysphonia has been shown to be a common sign of Huntington disease (HD), the extent of phonatory dysfunction in gene positive premanifest HD individuals remains unknown. The aim of the current study was to explore the possible occurrence of phonatory abnormalities in prodromal HD. METHOD Sustained vowel phonations were acquired from 28 premanifest HD individuals and 28 health...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Evidence of atrial mechanical dysfunction by acoustic quantification in abnormal relaxation and restrictive filling patterns of diastolic dysfunction in patients with coronary artery disease.

AIM This study made use of acoustic quantification (AQ) to investigate if left atrial (LA) mechanical function was impaired in patients with diastolic dysfunction, which might not be detected by conventional Doppler echocardiography. METHODS One hundred and ten patients with coronary artery disease (mean age 65+/-11 years, 80% male) underwent echocardiography prospectively while AQ was perfor...